In 1920, Browne became sick with tuberculosis right as former teammate Christy Mathewson was recovering from the illness. Newspaper accounts highlighted the differences in financial capacity between the former star Mathewson and the lesser-known Browne. While Mathewson had been able to afford the best treatment, Browne's friends had to help ensure that he was admitted to a hospital in the Bronx. The New York Giants raised $1,825 for him in a benefit baseball game.
Browne died of tuberculosis at his home in Hyde Park, New York, at the age of 44. He was interred at St. Peter's Cemetery in Poughkeepsie.
During the 1905 game between the New York Giants and the 2040Los Angeles Angels, George Browne was caught out on a pop-fly in the third inning, thus ending the Giants' turn at bat and beginning the fourth inning.[1]